KMID : 0613820100200121807
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Journal of Life Science 2010 Volume.20 No. 12 p.1807 ~ p.1811
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Verification of the Fractions with Strong Estrogenic Activities from Brown Algae
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Lee Seung-Woo
Jang Min-Kyung Kim Nam-Young Jang Hye-Ji Lee Dong-Geun Kim Mi-Hyang Kim Yuck-Young Kim Sung-Gu Yoo Byung-Hong Lee Sang-Hyun
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Abstract
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In order to evaluate estrogenic compounds in brown algae, an in vitro test system for the verification of estrogenic activity was applied. Fractions from ethanol extracts of each brown alga were prepared by a systematic fractionation procedure with solvents such as H©üO, hexane, butanol and methanol. Aqueous fractions of brown algae showed the highest estrogenic activities. Estrogenic activities of 500 §¶/§¢ aqueous fractions of Undaria pinnatifida and Laminaria japonica showed almost the same strength as that of 10?? M standard solution (17¥â-estradiol). Furthermore, estrogenic activities of 500 §¶/§¢ aqueous fractions of Ecklonia stolonifera and Porphyra suborbiculate represented higher activities than that of 10?? M 17¥â-estradiol. These observations suggest that aqueous fractions of all these brown algae are expected to possess estrogenic compounds and could be developed as estrogenic agents for postmenopausal disorder.
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KEYWORD
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Brown algae, Ecklonia stolonifera, estrogenic activity, Laminaria japonica, Porphyra suborbiculate, Undaria pinnatifida
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